Integration of Signaling Pathways Via Smad Proteins
作者： Etienne Labbé , Liliana Attisano
关键词:
摘要: TGF-β ligands are involved in most aspects of embryonic development and post-natal homeostasis numerous examples crosstalk with other signaling pathways have been described. The Smad proteins the extensively characterized signal transducers downstream superfamily secreted growth factors. In cases, shown to mediate this via formation DNA-bound transcriptional complexes pathways, thereby modifying promoter selectivity output. We will examine ability Smads integrate output through direct interactions
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