Maternal Chlamydia infection during pregnancy among younger mothers and risk of gastroschisis in singleton offspring
作者： Tessa Horslev , José N. Binongo , Vijaya Kancherla
DOI: 10.1002/BDR2.1179
关键词:
摘要: BACKGROUND Prevalence of gastroschisis has been increasing in the United States (US) since 1980s. Genital infection with Chlamydia also prevalence, particularly among younger women. The etiology is unknown. Ongoing research suggests multiple causal factors may be involved, including mothers during pregnancy. METHODS Using birth certificate data from 2014 US vital records, we conducted a population-based case-control study to examine association between prenatal exposure young women (16-25 years age) and singleton offspring. Cases consisted live births gastroschisis, controls had no major defects reported their certificate. Logistic regression analysis was used estimate crude adjusted odds ratios (cOR aOR) 95% confidence intervals (CI). RESULTS There were 809 cases (95.6% isolated cases) 1,260,293 controls. pregnancy 4.5% case 3.6% control (p = .21). Case significantly more likely (16-20 at time delivery compared (p < .0001). We found significant (cOR = 1.24; CI = 0.89-1.73 aOR = 1.06; CI: 0.66-1.70). CONCLUSION With caveat possible misclassification outcome variables data, offspring born mothers. Future studies should refine measures by focusing on relevant risk period biomarkers.
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