Prostate specific antigen levels in men older than 50 years without clinical evidence of prostatic carcinoma

摘要: In their derivation of normal prostate specific antigen (PSA) levels (0 to 4.0 ng./ml.) Hybritech used almost exclusively men less than 60 years old. The purpose this study was define PSA by age decade in older 50 without clinical evidence prostatic carcinoma or so-called cancer-free. We the cancer-free population as with a equal ng./ml. and nonsuspicious digital rectal examination, those an abnormality either parameter nonmalignant biopsy. A total 755 recruited for cancer detection using serum whom 728 fulfilled our criteria Newly derived mean standard deviation were 1.32 +/- 1.10 59-year group, 1.91 1.72 69-year group 2.36 1.98 70 79-year group. upper limits (mean+2 deviations) 3.5 5.4 6.3 apparent accuracy these new is strong but it declines next decade. data support further attempts at PSA, examination establish selection biopsy adequate sensitivity specificity.