Benzannulation via the Reaction of Ynamides and Vinylketenes. Application to the Synthesis of Highly Substituted Indoles

摘要: A two-stage “tandem strategy” for the synthesis of indoles with a high level substitution on six-membered ring is described. Benzannulation based reaction cyclobutenones ynamides proceeds via cascade four pericyclic reactions to produce multiply substituted aniline derivatives in which position ortho nitrogen can bear wide range functionalized substituents. In second stage tandem strategy, highly are generated acid-, base-, and palladium-catalyzed cyclization annulation processes.