Characterization of the regional intestinal kinetics of drug efflux in rat and human intestine and in Caco-2 cells.
作者： Vijaya D. Makhey , Ailan Guo , Daniel A. Norris , Peidi Hu , Jiansheng Yan
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摘要: Purpose. The aim of the present study was to investigate the transport kinetics of intestinal secretory processes in the jejunum, ileum and colon of rats and humans and in Caco-2 cells, …
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sci-hub.se 参考文章(38)
Jochem Alsenz, Hans Steffen, Rainer Alex, Active apical secretory efflux of the HIV protease inhibitors saquinavir and ritonavir in Caco-2 cell monolayers. Pharmaceutical Research. ,vol. 15, pp. 423- 428 ,(1998) , 10.1023/A:1011924314899
Scheper Rj, Meijer Cj, Izquierdo Ma, van der Valk P, Broxterman Hj, Flens Mj, Giaccone G, Scheffer Gl, Broad distribution of the multidrug resistance-related vault lung resistance protein in normal human tissues and tumors. American Journal of Pathology. ,vol. 148, pp. 877- 887 ,(1996)
Hiroshi Saitoh, Bruce J. Aungst, Possible involvement of multiple P-glycoprotein-mediated efflux systems in the transport of verapamil and other organic cations across rat intestine Pharmaceutical Research. ,vol. 12, pp. 1304- 1310 ,(1995) , 10.1023/A:1016217505990
Zenaida C. Gatmaitan, Irwin M. Arias, Structure and function of P-glycoprotein in normal liver and small intestine. Advances in pharmacology (San Diego). ,vol. 24, pp. 77- 97 ,(1993) , 10.1016/S1054-3589(08)60934-5
I Leier, G Jedlitschky, U Buchholz, S P Cole, R G Deeley, D Keppler, The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates. Journal of Biological Chemistry. ,vol. 269, pp. 27807- 27810 ,(1994) , 10.1016/S0021-9258(18)46856-1
Ken‐ichi Hosoya, Kwang‐Jin Kim, Vincent H. L. Lee, Age-dependent expression of P-glycoprotein gp170 in Caco-2 cell monolayers. Pharmaceutical Research. ,vol. 13, pp. 885- 890 ,(1996) , 10.1023/A:1016005212640
Gary D. Kruh, Toru Miki, Andrew Chan, Stuart A. Aaronson, Kim Myers, Kathleen Gaughan, Expression Complementary DNA Library Transfer Establishes mrp as a Multidrug Resistance Gene Cancer Research. ,vol. 54, pp. 1649- 1652 ,(1994)
J. Hunter, M.A. Jepson, T. Tsuruo, N.L. Simmons, B.H. Hirst, Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. Kinetics of vinblastine secretion and interaction with modulators. Journal of Biological Chemistry. ,vol. 268, pp. 14991- 14997 ,(1993) , 10.1016/S0021-9258(18)82429-2
Shu Hsing, Zenaida Gatmaitan, Irwin M. Arias, The function of Gp170, the multidrug-resistance gene product, in the brush border of rat intestinal mucosa Gastroenterology. ,vol. 102, pp. 879- 885 ,(1992) , 10.1016/0016-5085(92)90173-V
M. Donowitz, E. Emmer, J. McCullen, L. Reinlib, M. E. Cohen, R. P. Rood, J. Madara, G. W. Sharp, H. Murer, K. Malmstrom, Freeze-thaw and high-voltage discharge allow macromolecule uptake into ileal brush-border vesicles American Journal of Physiology-gastrointestinal and Liver Physiology. ,vol. 252, ,(1987) , 10.1152/AJPGI.1987.252.6.G723