Insulin and insulin-like growth factor-I: their role as risk factors in the development of diabetic cardiovascular disease

摘要: Experimental data support a role for insulin and insulin-like growth factor-I (IGF-I) in the pathophysiology of vascular complications diabetes. Clinical both hormones are less convincing, mainly because various studies vary methodologies, sample sizes, populations. So far, by epidemiological means, insulin's toxicity has been shown only middle-aged non-diabetic men. Furthermore, serious methodological problems hamper clear understanding IGF-I's significance this context. Definitive determination insulin, IGFs other factors development diabetic needs considerably more work. In any case, hyperinsulinemia is associated with cluster accepted risk cardiovascular disease which altogether resemble entire insulin-resistance syndrome.