Toxoplasma gondii infection reduces predator aversion in rats through epigenetic modulation in the host medial amygdala
作者： Shantala Arundhati Hari Dass , Ajai Vyas
DOI: 10.1111/MEC.12888
关键词:
摘要: Male rats (Rattus novergicus) infected with protozoan Toxoplasma gondii relinquish their innate aversion to the cat odours. This behavioural change is postulated increase transmission of parasite its definitive felid hosts. Here, we show that infection institutes an epigenetic in DNA methylation arginine vasopressin promoter medial amygdala male rats. Infected animals exhibit hypomethylation promoter, leading greater expression this nonapeptide. The also results activation vasopressinergic neurons after exposure odour. Furthermore, loss fear can be rescued by systemic hypermethylation and recapitulated directed amygdala. These demonstrate proximate mechanism underlying extended phenotype Rattus novergicus-Toxoplasma association.
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