Plasma and tissue pharmacokinetics of marbofloxacin in experimentally infected chickens with Mycoplasma gallisepticum and Escherichia coli

摘要: The plasma and tissue pharmacokinetics of marbofloxacin in chickens experimentally infected with Mycoplasma gallisepticum Escherichia coli were studied. Marbofloxacin was given to 66 by oral administration at a dosage 5 mg/kg b.w., once day for three days. Plasma, brain, kidney, liver, lung, muscle trachea collected concentrations analyzed high performance liquid chromatography method. In the chickens, maximal plasma, 1.84, 1.33, 7.35, 5.61, 3.12, 2.98, 4.51 g/mL (g); elimination half-lives 6.8, 2.74, 9.31, 8.45, 9.55, 11.53 5.46 h trachea, respectively. AUC calculated be 9.68, 8.04, 45.1, 27.03, 20.56, 19.47, 32.68 μg/mL (g) concentration tissues except brain exceeded AUC(tissue) /AUC(plasma) ranging from 2.01 4.66 Peak(tissue) /Peak(plasma) 1.62 3.99. results showed that administered orally 24 intervals may provide successful treatment chicken MG E. infection.