摘要: The main metabolic product of the fatty acid arachidonic (AA) in vascular tissue is prostacyclin, a potent vasodilator and inhibitor platelet aggregation (1). In contrast, platelets AA mainly converted to thromboxane A2, which vasoconstrictor inducer aggregation. An imbalance formation or interaction between these two metabolites has been implicated underlying process various thrombotic conditions as well atherosclerosis (2).
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E A Higgs, S Moncada, Arachidonate metabolism in blood cells and the vessel wall. Clinics in haematology. ,vol. 15, pp. 273- 292 ,(1986) , 10.1016/S0308-2261(18)30018-3
Y. Otsuka, A. DiPiero, E. Hirt, B. Brennaman, W. Lockette, Vascular relaxation and cGMP in hypertension American Journal of Physiology-heart and Circulatory Physiology. ,vol. 254, ,(1988) , 10.1152/AJPHEART.1988.254.1.H163
G. M. Rubanyi, P. M. Vanhoutte, Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor. American Journal of Physiology-heart and Circulatory Physiology. ,vol. 250, ,(1986) , 10.1152/AJPHEART.1986.250.5.H822
Marek W Radomski, Richard MJ Palmer, Salvador Moncada, None, The role of nitric oxide and cGMP in platelet adhesion to vascular endothelium. Biochemical and Biophysical Research Communications. ,vol. 148, pp. 1482- 1489 ,(1987) , 10.1016/S0006-291X(87)80299-1
H. E. Andrews, K. R. Bruckdorfer, R. C. Dunn, M. Jacobs, Low-density lipoproteins inhibit endothelium-dependent relaxation in rabbit aorta. Nature. ,vol. 327, pp. 237- 239 ,(1987) , 10.1038/327237A0
William Martin, Jerry A. Smith, David G. White, The mechanisms by which haemoglobin inhibits the relaxation of rabbit aorta induced by nitrovasodilators, nitric oxide, or bovine retractor penis inhibitory factor British Journal of Pharmacology. ,vol. 89, pp. 563- 571 ,(1986) , 10.1111/J.1476-5381.1986.TB11157.X
B. B. Weksler, A. J. Marcus, E. A. Jaffe, Synthesis of prostaglandin I2 (prostacyclin) by cultured human and bovine endothelial cells. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 74, pp. 3922- 3926 ,(1977) , 10.1073/PNAS.74.9.3922
Salvador Moncada, Ryszard J. Gryglewski, Stuart Bunting, John R. Vane, A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation Prostaglandins. ,vol. 12, pp. 715- 737 ,(1976) , 10.1016/0090-6980(76)90048-4
A R Folsom, C L Smith, R J Prineas, R H Grimm, Serum calcium fractions in essential hypertensive and matched normotensive subjects. Hypertension. ,vol. 8, pp. 11- 15 ,(1986) , 10.1161/01.HYP.8.1.11
SALVADOR MONCADA, Eighth Gaddum Memorial Lecture. University of London Institute of Education, December 1980. Biological importance of prostacyclin. British Journal of Pharmacology. ,vol. 76, pp. 3- 31 ,(1982) , 10.1111/J.1476-5381.1982.TB09186.X