Apoptosis in the Liver

摘要: The importance of apoptosis is evident in the liver during development and homeostasis biliary tree, apoptotic cell death, induced by reactive oxygen species via intrinsic signalling pathway, also increased aging liver. Apoptosis plays an important role pathogenesis, disarrangement death receptor pathways has been identified as a major contributor to initiation aggravation acute chronic injury. Dysregulation process, resulting too much or little potentially devastating effects. Over activation involving mediators such Fas, TNF-α, TGF-β1, members Bcl-2 family, can lead significant injuries, fulminant hepatic failure even sustained hepatocellular damage, occurs with toxic injury, viral hepatitis, alcoholic non disease cholestatic disorders. On contrary, inhibition promote proliferation transformation cells possibly carcinoma, protecting malignant hepatocytes from cellular suicide avoiding removal carrying mutated genes. Agents that modulate may be therapeutic benefit number diseases, research related type-specific signaling will provide new strategies for treatment.