Recognition of Cytosolic DNA Activates an IRF3-Dependent Innate Immune Response
作者： Daniel B. Stetson , Ruslan Medzhitov
DOI: 10.1016/J.IMMUNI.2005.12.003
关键词:
摘要: Nucleic acid recognition upon viral infection triggers type I interferon production. Viral RNA is detected by both endosomal, TLR-dependent and cytosolic, RIG-I/MDA5-dependent pathways. TLR9 the only known sensor of foreign DNA; it unknown whether innate immune DNA exists in cytosol. Here we present evidence that cytosolic activates a potent response to invasive bacterium Listeria monocytogenes. The noninvasive Legionella pneumophila an identical through its IV secretion system. Activation interferons TLR independent requires IRF3 but occurs without detectable activation NF-kappaB MAP kinases. Microarray analyses reveal unique overlapping gene-expression program activated compared TLR9- responses. These findings define linked
unirioja.es
elsevier.com
core.ac.uk 
sci-hub.se 参考文章(59)
Virginia L. Waters, Conjugation between bacterial and mammalian cells. Nature Genetics. ,vol. 29, pp. 375- 376 ,(2001) , 10.1038/NG779
Hiroaki Hemmi, Osamu Takeuchi, Taro Kawai, Tsuneyasu Kaisho, Shintaro Sato, Hideki Sanjo, Makoto Matsumoto, Katsuaki Hoshino, Hermann Wagner, Kiyoshi Takeda, Shizuo Akira, A Toll-like receptor recognizes bacterial DNA. Nature. ,vol. 408, pp. 740- 745 ,(2000) , 10.1038/35047123
Masahiro Yamamoto, Soh Yamazaki, Satoshi Uematsu, Shintaro Sato, Hiroaki Hemmi, Katsuaki Hoshino, Tsuneyasu Kaisho, Hirotaka Kuwata, Osamu Takeuchi, Koichiro Takeshige, Tatsuya Saitoh, Shoji Yamaoka, Naoki Yamamoto, Shunsuke Yamamoto, Tatsushi Muta, Kiyoshi Takeda, Shizuo Akira, Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IκBζ Nature. ,vol. 430, pp. 218- 222 ,(2004) , 10.1038/NATURE02738
Silvia Stockinger, Benjamin Reutterer, Barbara Schaljo, Carola Schellack, Sylvia Brunner, Tilo Materna, Masahiro Yamamoto, Shizuo Akira, Tadatsugu Taniguchi, Peter J. Murray, Mathias Müller, Thomas Decker, IFN regulatory factor 3-dependent induction of type I IFNs by intracellular bacteria is mediated by a TLR- and Nod2-independent mechanism. Journal of Immunology. ,vol. 173, pp. 7416- 7425 ,(2004) , 10.4049/JIMMUNOL.173.12.7416
G. R. Klimpel, D. W. Niesel, Yang Jo Cho, C. B. Hess, Bacterial invasion of fibroblasts induces interferon production. Journal of Immunology. ,vol. 138, pp. 3949- 3953 ,(1987)
Ryan M. O’Connell, Sagar A. Vaidya, Andrea K. Perry, Supriya K. Saha, Paul W. Dempsey, Genhong Cheng, Immune Activation of Type I IFNs by Listeria monocytogenes Occurs Independently of TLR4, TLR2, and Receptor Interacting Protein 2 but Involves TANK-Binding Kinase 1 Journal of Immunology. ,vol. 174, pp. 1602- 1607 ,(2005) , 10.4049/JIMMUNOL.174.3.1602
Ken J. Ishii, Koichi Suzuki, Cevayir Coban, Fumihiko Takeshita, Yasushi Itoh, Hana Matoba, Leonard D. Kohn, Dennis M. Klinman, Genomic DNA Released by Dying Cells Induces the Maturation of APCs Journal of Immunology. ,vol. 167, pp. 2602- 2607 ,(2001) , 10.4049/JIMMUNOL.167.5.2602
M. O'Riordan, C. H. Yi, R. Gonzales, K.-D. Lee, D. A. Portnoy, Innate recognition of bacteria by a macrophage cytosolic surveillance pathway. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 99, pp. 13861- 13866 ,(2002) , 10.1073/PNAS.202476699
A. Y. Karpova, M. Trost, J. M. Murray, L. C. Cantley, P. M. Howley, Interferon regulatory factor-3 is an in vivo target of DNA-PK Proceedings of the National Academy of Sciences of the United States of America. ,vol. 99, pp. 2818- 2823 ,(2002) , 10.1073/PNAS.052713899
Siddharth Balachandran, Emmanuel Thomas, Glen N. Barber, A FADD-dependent innate immune mechanism in mammalian cells Nature. ,vol. 432, pp. 401- 405 ,(2004) , 10.1038/NATURE03124