Modeling Cell Decisions in Bone Formation

摘要: The process of bone formation involves several mechanisms, which can manifest dysfunctions such as osteoporosis in case imbalances between them. In basic terms, osteo-adipo progenitors derive from the marrow, and depending on multiple stimulus signals, stay their progenitor state (preosteoblast) or differentiate to form fat tissue [3]. We point model dynamics cell decisions preosteoblasts osteoblasts, considering stimulatory important role epigenetics. Given a cell, presence specific epigenetic marks favors expression biomarker genes posterior differentiation into osteoblasts. Starting with group marked cells, we silico proliferation cells inheritance. consider hybrid system [2, 8] each grows continuously over time until being ready divide, success division inheritance includes randomness. Stimulating predicts increase number osteoblasts helping testing medical treatments production vitro.