ATP and P2X Purinoceptors in Urinary Tract Disorders

作者: Anthony P. D. W. Ford , Debra A. Cockayne

DOI: 10.1007/978-3-642-16499-6_22

关键词:

摘要: The pharmacological concept of specifically targeting purinoceptors (receptors for ATP and related nucleotides) has emerged over the last two decades in quest novel, differentiated therapeutics. Investigations from many laboratories have established a prominent role functional regulation most tissue organ systems, including urinary tract, under normal pathophysiological conditions. In particular case signaling via P2X1 receptors participates efferent control detrusor smooth muscle excitability, this function may be heightened disease aging. Perhaps greater interest, also appears to involved bladder sensation, operating activation P2X3-containing on sensory afferent neurones, both peripheral terminals within tract tissues (e.g., ureters, bladder) central synapses dorsal horn spinal cord. Such findings are based results classical localization studies nonhuman human tissues, gene knockout mice, using recently identified antagonists – some which progressed as candidate drug molecules. Based recent advances field, it is apparent that development selective these will occur could lead therapies offering better relief storage, voiding, symptoms patients, while minimizing systemic side effects curb clinical effectiveness current urologic medicines.

参考文章(219)
K E Anderson, Pharmacology of lower urinary tract smooth muscles and penile erectile tissues. Pharmacological Reviews. ,vol. 45, pp. 253- 308 ,(1993)
Mitchell A. Hansen, Vladimir J. Balcar, Julian A. Barden, Max R. Bennett, The distribution of single P2x1-receptor clusters on smooth muscle cells in relation to nerve varicosities in the rat urinary bladder Journal of Neurocytology. ,vol. 27, pp. 529- 539 ,(1998) , 10.1023/A:1006908010642
S Bishara, H Gao, M Malone-Lee, S Clark, R Lunawat, S Khan, R Khasriya, B King, J Malone-Lee, None, Increased ATP mediated contraction of isolated detrusor cells of patients with outflow obstruction Neurourology and Urodynamics. ,(2009)
Geoffrey Burnstock, Gillian E. Knight, Cellular distribution and functions of P2 receptor subtypes in different systems International Review of Cytology-a Survey of Cell Biology. ,vol. 240, pp. 31- 304 ,(2004) , 10.1016/S0074-7696(04)40002-3
Elizabeth Burcher, Kylie J. Mansfield, ATP release during cystometry in women with detrusor overactivity and painful bladder syndrome: contribution to 'urgency'? Neurourology and Urodynamics. ,vol. 28, pp. 838- ,(2009)
Kazuhide Inoue, Makoto Tsuda, Schuichi Koizumi, Chronic pain and microglia: The role of ATP Novartis Foundation symposium. ,vol. 261, pp. 55- 67 ,(2004) , 10.1002/0470869127.CH6
Y. Yiangou, P. Facer, A. Ford, C. Brady, O. Wiseman, C.J. Fowler, P. Anand, Capsaicin receptor VR1 and ATP-gated ion channel P2X3 in human urinary bladder BJU International. ,vol. 87, pp. 774- 779 ,(2001) , 10.1046/J.1464-410X.2001.02190.X
Naoki Yoshimura, William C. de Groat, Increased Excitability of Afferent Neurons Innervating Rat Urinary Bladder after Chronic Bladder Inflammation The Journal of Neuroscience. ,vol. 19, pp. 4644- 4653 ,(1999) , 10.1523/JNEUROSCI.19-11-04644.1999
Rita Bardoni, Peter A. Goldstein, C. Justin Lee, Jianguo G. Gu, Amy B. MacDermott, ATP P2XReceptors Mediate Fast Synaptic Transmission in the Dorsal Horn of the Rat Spinal Cord The Journal of Neuroscience. ,vol. 17, pp. 5297- 5304 ,(1997) , 10.1523/JNEUROSCI.17-14-05297.1997