作者: Anthony P. D. W. Ford , Debra A. Cockayne
DOI: 10.1007/978-3-642-16499-6_22
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摘要: The pharmacological concept of specifically targeting purinoceptors (receptors for ATP and related nucleotides) has emerged over the last two decades in quest novel, differentiated therapeutics. Investigations from many laboratories have established a prominent role functional regulation most tissue organ systems, including urinary tract, under normal pathophysiological conditions. In particular case signaling via P2X1 receptors participates efferent control detrusor smooth muscle excitability, this function may be heightened disease aging. Perhaps greater interest, also appears to involved bladder sensation, operating activation P2X3-containing on sensory afferent neurones, both peripheral terminals within tract tissues (e.g., ureters, bladder) central synapses dorsal horn spinal cord. Such findings are based results classical localization studies nonhuman human tissues, gene knockout mice, using recently identified antagonists – some which progressed as candidate drug molecules. Based recent advances field, it is apparent that development selective these will occur could lead therapies offering better relief storage, voiding, symptoms patients, while minimizing systemic side effects curb clinical effectiveness current urologic medicines.