Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors as Preclinical Immunotherapy Tool Compounds

作者: Xavier Fradera , Erin F DiMauro , Joey L Methot , Samuel M Levi , Abdelghani Achab

DOI: 10.1021/ACSMEDCHEMLETT.1C00096

关键词:

摘要: … and other structural classes examined as HPK1 inhibitors was a distinct “bell-shaped” IL-… HPK1 inhibitor titration. While a sigmoidal or “sustained” IL-2 response curve to HPK1 inhibitor …

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