An automated system for rapid evaluation of high-density electrode arrays in neural prostheses

作者: Sam E John , Mohit N Shivdasani , James Leuenberger , James B Fallon , Robert K Shepherd

DOI: 10.1088/1741-2560/8/3/036011

关键词:

摘要: The success of high-density electrode arrays for use in neural prostheses depends on efficient impedance monitoring and fault detection. Conventional methods testing detection are time consuming not always suited vivo assessment arrays. Additionally, the ability to evaluate impedances faults such as open short circuits, both vitro vivo, important ensure safe effective stimulation. In this work we describe an automated system rapid evaluation uses a current pulse similar that used stimulate tissue measures voltage across order calculate impedance. switching was validated by emulating array using light-emitting diodes resistor-capacitor network. tested range commercially available in-house developed accurately identified 84-electrode less than 20 s reliably measured up 110 kΩ 200 µA, 250 µs per phase pulse. This has direct application screening clinical experimental settings.

参考文章(33)
Kabilar Gunalan, David J. Warren, Justin D. Perry, Richard A. Normann, Gregory A. Clark, An automated system for measuring tip impedance and among-electrode shunting in high-electrode count microelectrode arrays. Journal of Neuroscience Methods. ,vol. 178, pp. 263- 269 ,(2009) , 10.1016/J.JNEUMETH.2008.12.020
Joseph F. Rizzo, John Wyatt, John Loewenstein, Shawn Kelly, Doug Shire, Perceptual Efficacy of Electrical Stimulation of Human Retina with a Microelectrode Array during Short-Term Surgical Trials Investigative Ophthalmology & Visual Science. ,vol. 44, pp. 5362- 5369 ,(2003) , 10.1167/IOVS.02-0817
Carrie Newbold, Rachael Richardson, Christie Q Huang, Dusan Milojevic, Robert Cowan, Robert Shepherd, An in vitro model for investigating impedance changes with cell growth and electrical stimulation: implications for cochlear implants. Journal of Neural Engineering. ,vol. 1, pp. 218- 227 ,(2004) , 10.1088/1741-2560/1/4/005
S. B. Brummer, L. S. Robblee, F. T. Hambrecht, CRITERIA FOR SELECTING ELECTRODES FOR ELECTRICAL STIMULATION: THEORETICAL AND PRACTICAL CONSIDERATIONS Annals of the New York Academy of Sciences. ,vol. 405, pp. 159- 171 ,(1983) , 10.1111/J.1749-6632.1983.TB31628.X
T.L. Rose, L.S. Robblee, Electrical stimulation with Pt electrodes. VIII. Electrochemically safe charge injection limits with 0.2 ms pulses (neuronal application) IEEE Transactions on Biomedical Engineering. ,vol. 37, pp. 1118- 1120 ,(1990) , 10.1109/10.61038
Mohit N Shivdasani, Chi D Luu, Rosemary Cicione, James B Fallon, Penny J Allen, James Leuenberger, Gregg J Suaning, Nigel H Lovell, Robert K Shepherd, Chris E Williams, Evaluation of stimulus parameters and electrode geometry for an effective suprachoroidal retinal prosthesis. Journal of Neural Engineering. ,vol. 7, pp. 036008- 036008 ,(2010) , 10.1088/1741-2560/7/3/036008
Joseph Weinman, Jonah Mahler, AN ANALYSIS OF ELECTRICAL PROPERTIES OF METAL ELECTRODES. Medical Electronics & Biological Engineering. ,vol. 2, pp. 299- 310 ,(1964) , 10.1007/BF02474626
Michael Tykocinski, Lawrence T Cohen, Robert S Cowan, Measurement and analysis of access resistance and polarization impedance in cochlear implant recipients. Otology & Neurotology. ,vol. 26, pp. 948- 956 ,(2005) , 10.1097/01.MAO.0000185056.99888.F3
Ralf Hornig, Thomas Laube, Peter Walter, Michaela Velikay-Parel, Norbert Bornfeld, Matthias Feucht, Harun Akguel, Gernot Rössler, Nils Alteheld, Dietmar Lütke Notarp, John Wyatt, Gisbert Richard, A method and technical equipment for an acute human trial to evaluate retinal implant technology. Journal of Neural Engineering. ,vol. 2, ,(2005) , 10.1088/1741-2560/2/1/014