Antimalarial agents, 2. Artesunate, an inhibitor of cytochrome oxidase activity in Plasmodium berghei.
作者： YI Zhao , Wilma Kane Hanton , Kuo-Hsiung Lee , None
DOI: 10.1021/NP50043A018
关键词:
摘要: The activity of the cytochrome oxidase, which is located in plasma and nuclear food-vacuole-limiting membranes as well mitochondria trophozoites Plasmodium berghei, was inhibited completely by sodium artesunate, an antimalarial drug, vitro at 1 mM vivo 100 mg/kg iv. This enzyme appears to be a target for mechanism action artesunate qinghaosu.
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