Internalization of ionotropic glutamate receptors in response to mGluR activation.
作者： Eric M. Snyder , Benjamin D. Philpot , Kimberly M. Huber , Xin Dong , Justin R. Fallon
DOI: 10.1038/NN746
关键词:
摘要: Activation of group 1 metabotropic glutamate receptors (mGluRs) stimulates dendritic protein synthesis and long-term synaptic depression (LTD), but it remains unclear how these effects are related. Here we provide evidence that a consequence mGluR activation in the hippocampus is rapid loss both AMPA NMDA from synapses. Like mGluR-LTD, stable expression this change requires synthesis. These data suggest mGluR-LTD at least partly postsynaptic, functional regulation receptor trafficking.
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