Effect of sex on kidney transplants.

摘要: 1. In 9 yearly cohorts from 1978 to 1986, male and female recipients had the same one-year graft survival rates for first cadaver donor grafts. For regrafts, superior in 2 out of years. 2. contrast, cohorts, grafts a lower than donors 8 comparisons, although difference was not statistically significant. regrafts last 5 years, 4 different years females significant rate compared males. 3. The kidneys especially evident CsA-treated regrafted patients, similar tendency noted also non-CsA-treated regraft patients. 4. Grafts older 30 5. depressed effect affected by recipient's sex or original disease. 6. Female either trauma nontrauma yielded rates. Thus, cause death is probably principal explanation effect. Since males more often die trauma, it initially thought that could be attributed mode donor. 7. Regrafts living-related who differ one HLA haplotype donors. 8. It unlikely sex-associated histocompatibility antigen exists clinical kidney transplant situation since received successive rejection does sensitize recipient second graft, when result survival. 9. Poor mismatches HLA-A, B, DR antigens were deleterious with With CsA, all categories mismatches. 10. Transfusions did influence level panel reactive antibody affect kidneys. 11. apparent even month after transplantation.