Digital Real-world Data Suggest Patient Preference for Tadalafil over Sildenafil in Patients with Erectile Dysfunction.

摘要: Abstract Background Erectile dysfunction (ED) is a major care problem worldwide. Tadalafil and sildenafil are the two most common phosphodiesterase-5 inhibitors (PDE5is) used to treat ED. Objective This study aimed evaluate patient data of large online prescription platform (OPP), specifically analyzing preference for tadalafil over sildenafil. Design, setting, participants Data from prospectively collected German OPP were retrospectively analyzed. dataset included patients with history taking one or both substances (n = 26 821). Outcome measurements statistical analysis ED baseline characteristics derived medical questionnaires PDE5i prescriptions between May 2019 2020. Order behavior was analyzed in who ordered time. We applied Kruskal-Wallis tests, χ² fisher’s exact tests analysis. Results limitations Baseline comparable PDE5is median age 49 yr (sildenafil [interquartile range {IQR} 38–57]; [IQR 39–56]), body mass index (BMI) 26 kg/m² 24.54–29.03]; 24.49–28.69]), onset time >12 mo [87%]; [88%]), presence morning erections [62%]; [61%]). increased significantly 30% (first order) 80% (last had already tested drugs. Patients ≤40 yr, BMI ≤25 kg/m², sustained preferred Conclusions Using database information an OPP, shown PDE5is. particularly pronounced erections. A well-managed can be research on more complex health services. Patient summary Analysis platforms provide benefit identifying young treatment-naive early-stage disease, which highlighted by fact that about two-thirds our still maintained spontaneous once developed this drug.