Insulin-secretion abnormalities and clinical deterioration related to impaired glucose tolerance in cystic fibrosis.

摘要: Objective: To evaluate insulin-secretion kinetics and insulin sensitivity in cystic fibrosis (CF) patients with normal glucose tolerance (CF-NGT), impaired (CF-IGT) or CF-related diabetes (CFRD), the potential effects of moderate hyperglycemia on clinical nutritional status. Design methods: Cross-sectional study including 50 outpatients CF. Patients underwent both oral (OGGT) intravenous (IVGTT) tests order to assess secretion peripheral sensitivity. Homeostasis assessment model OGGT were used investigate Forced expiratory volume first second (FEV1) forced vital capacity (FVC) measured pulmonary function. Body mass index (BMI) was determined Results: Insulin significantly decreased (and delayed at OGTT) CFRD group (n ¼ 9) versus CF-IGT 10) CF-NGT 31). different groups group. FEV1, FVC BMI presented a significant linear correlation plasma value 120 min OGTT lower group, whereas no differences found between groups. Conclusions: CF IGT present diminished increased resistance, correlating worse status, undernutrition These findings open question whether early treatment mild alterations metabolism secretagogues short-action may lead improvement status patients.