DNA Repair and Recombination

摘要: Investigations using filamentous fungi have made major contributions to the understanding of core biological processes DNA repair and recombination, as certain model species provide particularly favorable opportunities for insight. The Ascomycete fungi, including fungus Neurospora crassa, conveniently a full set products single meiosis packaged in spores inside ascus. study began with discovery photoreactivation UV-sensitive mutants bacteria, followed by isolation characterization sensitivity UV, IR, chemical mutagens both Escherichia coli yeast S. cerevisiae. segregation patterns parental recombinant chromosomes from yeasts considered stimulated Whitehouse Holliday formulate models meiotic aspects remain valid this day. Research into recombination can now proceed apace deletion each annotated gene predicted role these processes, enabling move beyond individual systems an more complex networks. Epigenetic control metabolism undoubtedly plays part recombination. sensitive remains indispensable tool if comprehensive is developed. greater genetic complexity than are similar organisms such mammals. will continue efficient investigation.