Chapter 21 – Multiple Sclerosis and Depression: A Neuroimmunological Perspective

摘要: Publisher Summary This chapter examines whether depression is coincidental with multiple sclerosis (MS), or if it a symptom, consequence, side effect of the treatment, some combination these. The also explores antecedent risk factors, such as previous psychiatric history, family history affective disorder, influence prevalence both before and during discusses likely causes in MS population. exceeds 100 cases per 100,000 persons many parts world, including much Europe North America. early onset (typically between 20 40 years age), lifelong duration, unpredictable course result major burdens to individual, society, well reduced quality life work productivity. Depression perhaps recognized less often than should be. A depression-triggered negativistic mindset, seldom acknowledged, usual reason for refusal start immunomodulatory treatment. negatively impacts compliance once treatment has begun.