Pyridine Ruthenium(III) complexes entrapped in liposomes with enhanced cytotoxic properties in PC-3 prostate cancer cells

摘要: Abstract The first aim of the present study is development a new ruthenium(III) complex, belonging to NAMI-A class, with potentially high cytotoxic ability. presence fully protected sugar moiety as ruthenium ligand should increase complex ability cross cellular membranes. Furthermore, it sets this molecule in area biocompatible agents tumor drug. second, more relevant, purpose verify complexes activity after loading into liposomes. We reported characterization and vitro biological assays pyridine derivatives loaded Egg l -α-phosphatidylcholine cholesterol/DSPE-PEG Dynamic light scattering estimates that sizes all obtained liposomes are 100 nm range. This value suitable for vivo use. release kinetic allowed selecting best ratio between lipid fraction metal be tested experiments. growth inhibitory effects both liposomal free PC-3 prostate cancer cell lines demonstrate liposome entrapped (III) suggesting additional role further antimetastatic function.