A population-based case-control study of the tumor necrosis factor alpha-308 polymorphism in multiple sclerosis

摘要: Tumor necrosis factor alpha (TNFα) expression in enhanced patients with active MS and other inflammatory disease. A guanine-to-adenine polymorphism at position -308 of the TNFα promoter region (the TNF2 allele) is associated increased expression. We evaluated 110 derived from an Olmsted County, MN, prevalence study. Three patient cohorts (autoimmune, serious infectious illness, neurologic diseases) matched controls were a Mayo Clinic DNA bank. used polymerase chain reaction amplification specific alleles to screen for allele determine zygosity. found one homozygote 29 heterozygotes patients. There was no association between presence or disease categories by matched-pair group analyses.