Preparation of fine W/O/W emulsion through membrane filtration of coarse W/O/W emulsion and disappearance of the inclusion of outer phase solution
作者： Motohiro Shima , Yohei Kobayashi , Takao Fujii , Miyono Tanaka , Yukitaka Kimura
DOI: 10.1016/S0268-005X(03)00042-0
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摘要: Abstract A water-in-oil-in-water (W/O/W) emulsion was prepared as a carrier system for the daily uptake of bioactive compound using decaglycerol monolaurate and hexaglyceryl condensed ricinolate hydrophilic lipophilic surfactants, respectively. 1,3,6,8-Pyrenetetrasulfonic acid tetrasodium salt (PTSA) used model substance. Membrane filtration coarse W/O/W with rotor/stator homogenizer produced fine which had mean oil-droplet diameter 90%. Microscopic observations revealed that fluorescent material in outer-phase solution included into oil phase during homogenization. It suggested because to produce both O/W emulsions, some part outer would be second The fluorescence shown droplets diminished after membrane emulsification. This phenomenon released from interior
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