Immunization with inactivated Middle East Respiratory Syndrome coronavirus vaccine leads to lung immunopathology on challenge with live virus.
作者： Anurodh Shankar Agrawal , Xinrong Tao , Abdullah Algaissi , Tania Garron , Krishna Narayanan
DOI: 10.1080/21645515.2016.1177688
关键词:
摘要: To determine if a hypersensitive-type lung pathology might occur when mice were given an inactivated MERS-CoV vaccine and challenged with infectious virus as was seen SARS-CoV vaccines, we prepared vaccinated vaccine. Neutralizing antibody induced by without adjuvant reduced in after challenge. Lung mononuclear infiltrates occurred all groups challenge but increased that contained eosinophils increases the eosinophil promoting IL-5 IL-13 cytokines only groups. Inactivated appears to carry risk from infection is similar found vaccines infection.
utsystem.edu参考文章(21)
Ben Embarek Pk, Van Kerkhove, Middle East respiratory syndrome coronavirus (MERS-CoV): current situation 3 years after the virus was first identified. Relevé épidémiologique hebdomadaire / Section d'hygiène du Secrétariat de la Société des Nations = Weekly epidemiological record / Health Section of the Secretariat of the League of Nations. ,vol. 90, pp. 245- ,(2015)
Teresa R. Johnson, Robert A. Parker, Joyce E. Johnson, Barney S. Graham, IL-13 Is Sufficient for Respiratory Syncytial Virus G Glycoprotein-Induced Eosinophilia After Respiratory Syncytial Virus Challenge The Journal of Immunology. ,vol. 170, pp. 2037- 2045 ,(2003) , 10.4049/JIMMUNOL.170.4.2037
Sang-Moo Kang, Young-Tae Lee, Eun-Ju Ko, Hye Suk Hwang, Jong Seok Lee, Ki-Hye Kim, Young-Man Kwon, Respiratory syncytial virus-like nanoparticle vaccination induces long-term protection without pulmonary disease by modulating cytokines and T-cells partially through alveolar macrophages. International Journal of Nanomedicine. ,vol. 10, pp. 4491- 4505 ,(2015) , 10.2147/IJN.S83493
ALBERT Z. KAPIKIAN, REGINALD H. MITCHELL, ROBERT M. CHANOCK, RUTH A. SHVEDOFF, C. ELEANOR STEWART, AN EPIDEMIOLOGIC STUDY OF ALTERED CLINICAL REACTIVITY TO RESPIRATORY SYNCYTIAL (RS) VIRUS INFECTION IN CHILDREN PREVIOUSLY VACCINATED WITH AN INACTIVATED RS VIRUS VACCINE American Journal of Epidemiology. ,vol. 89, pp. 405- 421 ,(1969) , 10.1093/OXFORDJOURNALS.AJE.A120954
Thomas A. Wynn, Fibrotic disease and the TH1/TH2 paradigm Nature Reviews Immunology. ,vol. 4, pp. 583- 594 ,(2004) , 10.1038/NRI1412
M. Bolles, D. Deming, K. Long, S. Agnihothram, A. Whitmore, M. Ferris, W. Funkhouser, L. Gralinski, A. Totura, M. Heise, R. S. Baric, A Double-Inactivated Severe Acute Respiratory Syndrome Coronavirus Vaccine Provides Incomplete Protection in Mice and Induces Increased Eosinophilic Proinflammatory Pulmonary Response upon Challenge Journal of Virology. ,vol. 85, pp. 12201- 12215 ,(2011) , 10.1128/JVI.06048-11
Naru Zhang, Rudragouda Channappanavar, Cuiqing Ma, Lili Wang, Jian Tang, Tania Garron, Xinrong Tao, Sumaiya Tasneem, Lu Lu, Chien-Te K Tseng, Yusen Zhou, Stanley Perlman, Shibo Jiang, Lanying Du, Identification of an ideal adjuvant for receptor-binding domain-based subunit vaccines against Middle East respiratory syndrome coronavirus. Cellular & Molecular Immunology. ,vol. 13, pp. 180- 190 ,(2016) , 10.1038/CMI.2015.03
Y W Tang, B S Graham, Anti-IL-4 treatment at immunization modulates cytokine expression, reduces illness, and increases cytotoxic T lymphocyte activity in mice challenged with respiratory syncytial virus. Journal of Clinical Investigation. ,vol. 94, pp. 1953- 1958 ,(1994) , 10.1172/JCI117546
Richard M. Locksley, Asthma and Allergic Inflammation Cell. ,vol. 140, pp. 777- 783 ,(2010) , 10.1016/J.CELL.2010.03.004
X. Tao, F. Mei, A. Agrawal, C. J. Peters, T. G. Ksiazek, X. Cheng, C.-T. K. Tseng, Blocking of Exchange Proteins Directly Activated by cAMP Leads to Reduced Replication of Middle East Respiratory Syndrome Coronavirus Journal of Virology. ,vol. 88, pp. 3902- 3910 ,(2014) , 10.1128/JVI.03001-13