Selective chemisorption and detoxification of aflatoxins by phyllosilicate clay.

摘要: Practical and effective strategies for the detoxification of aflatoxins are critically needed. We have shown that a phyllosilicate clay (HSCAS): i) tightly binds in aqueous solutions, including milk; ii) markedly decreases bioavailability radiolabeled aflatoxins; iii) greatly diminishes aflatoxicosis young animals, i.e., rats, chickens, turkeys, lambs, pigs; iv) reduces level aflatoxin M1 milk from lactating dairy cattle goats. In further studies, ligands with one or more functional groups common were reacted HSCAS vitro an attempt to elucidate specificity mechanism tight binding (or chemisorption). A chemisorption index (C alpha) was developed, allowing direct comparison various zeolitic minerals HSCAS. Chemisorption indices determined by HPLC analysis extracts supernatants sorbed pellets (exhaustively extracted methanol chloroform). The beta-dicarbonyl system found be essential Comparison classes compounds spectral data (DRIFTS) indicated molecular may involve chelation metal ions moiety aflatoxin. Computer modeling utilized provide additional information. Preliminary evidence suggests B1 react at surfaces within interlayers particles. With knowledge involved, it has been possible enhance propensity aflatoxins.