摘要: Some cancer cells depend on the function of specific molecules for their growth, survival, and metastatic potential. Targeting these critical has arguably been best therapy as demonstrated by success tamoxifen trastuzumab in breast cancer. This review will evaluate type I IGF receptor (IGF-IR) a potential target therapy. As new drugs come forward targeting this system, several issues need to be addressed early clinical trials using agents.
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sci-hub.se 参考文章(48)
Haim Werner, Bethel Stannard, Mark A. Bach, Charles T. Roberts, Derek LeRoith, Regulation of Insulin-Like Growth Factor I Receptor Gene Expression in Normal and Pathological States Advances in Experimental Medicine and Biology. ,vol. 293, pp. 263- 272 ,(1991) , 10.1007/978-1-4684-5949-4_24
Dominic J. Withers, Deborah J. Burks, Heather H. Towery, Shari L. Altamuro, Carrie L. Flint, Morris F. White, Irs-2 coordinates Igf-1 receptor-mediated β-cell development and peripheral insulin signalling Nature Genetics. ,vol. 23, pp. 32- 40 ,(1999) , 10.1038/12631
Julie S. Hartell, Jeffrey S Miller, Deepali Sachdev, Douglas Yee, Shu Lian Li, Yoko Fujita-Yamaguchi, A Chimeric Humanized Single-Chain Antibody against the Type I Insulin-like Growth Factor (IGF) Receptor Renders Breast Cancer Cells Refractory to the Mitogenic Effects of IGF-I Cancer Research. ,vol. 63, pp. 627- 635 ,(2003)
Gina M. Leinninger, Eva L. Feldman, Insulin-like growth factors in the treatment of neurological disease. Endocrine development. ,vol. 9, pp. 135- 159 ,(2005) , 10.1159/000085763
Douglas Burtrum, Zhenping Zhu, Dan Lu, Donna Marie Anderson, Marie Prewett, Daniel S Pereira, Rajiv Bassi, Rashed Abdullah, Andrea T Hooper, Henry Koo, Xenia Jimenez, Danielle Johnson, Robin Apblett, Paul Kussie, Peter Bohlen, Larry Witte, Daniel J Hicklin, Dale L Ludwig, None, A Fully Human Monoclonal Antibody to the Insulin-Like Growth Factor I Receptor Blocks Ligand-Dependent Signaling and Inhibits Human Tumor Growth in Vivo Cancer Research. ,vol. 63, pp. 8912- 8921 ,(2003)
F. Frasca, G. Pandini, P. Scalia, L. Sciacca, R. Mineo, A. Costantino, I. D. Goldfine, A. Belfiore, R. Vigneri, Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells. Molecular and Cellular Biology. ,vol. 19, pp. 3278- 3288 ,(1999) , 10.1128/MCB.19.5.3278
Nancy E Dagdigian, Walter A Blättler, Thomas Chittenden, Lisa M Garrett, Erin K Maloney, Rajeeva Singh, Katherine M Connors, Xiao-Mai Zhou, Jennifer L McLaughlin, An anti-insulin-like growth factor I receptor antibody that is a potent inhibitor of cancer cell proliferation. Cancer Research. ,vol. 63, pp. 5073- 5083 ,(2003)
Daiana Vasilcanu, Ada Girnita, Leonard Girnita, Radu Vasilcanu, Magnus Axelson, Olle Larsson, The cyclolignan PPP induces activation loop-specific inhibition of tyrosine phosphorylation of the insulin-like growth factor-1 receptor. Link to the phosphatidyl inositol-3 kinase/Akt apoptotic pathway. Oncogene. ,vol. 23, pp. 7854- 7862 ,(2004) , 10.1038/SJ.ONC.1208065
Renato Baserga, The insulin-like growth factor-I receptor as a target for cancer therapy Expert Opinion on Therapeutic Targets. ,vol. 9, pp. 753- 768 ,(2005) , 10.1517/14728222.9.4.753
Jack F. Youngren, Karissa Gable, Cristina Penaranda, Betty A. Maddux, Marianna Zavodovskaya, Margaret Lobo, Michael Campbell, John Kerner, Ira D. Goldfine, Nordihydroguaiaretic acid (NDGA) inhibits the IGF-1 and c-erbB2/HER2/neu receptors and suppresses growth in breast cancer cells. Breast Cancer Research and Treatment. ,vol. 94, pp. 37- 46 ,(2005) , 10.1007/S10549-005-6939-Z