A Predictive Approach to Identify Clinical State, Emotional Valence and Pharmacologic Effect in Human Task-Based fMRI Data

摘要: Clinically approved antidepressants modulate the brain’s emotional valence circuits, suggesting that response of these circuits could serve as a biomarker for screening candidate antidepressant drugs. Here, we apply cross-validated predictive model to classify clinical state, valence, and pharmacologic effect across eight task-based fMRI studies (n=306) administration on face processing.