A comparison of the virus-specific polypeptides of encephalomyocarditis virus, human rhinovirus-1A, and poliovirus☆

摘要: Abstract Encephalomyocarditis (EMC) virus, human rhinovirus-1A (HRV-1A), and poliovirus are each representatives of a different, major subgroup the picornaviruses. In this comparative study patterns biosynthesis virus-specific polypeptides these three viruses were examined in detail. The molecular weight molar ratio polypeptide genetic map virus determined, kinetics cleavage analogous precursor contrasted. Previous work has shown that there main families EMC polypeptides. Translation viral ribonucleic acid generates at least primary products, A, F, C. Polypeptide A undergoes successive cleavages to produce four capsid F is stable. C cleaves form D, which turn E. Evolutionary pressures on have resulted extensive differences antigenicity virions. addition, it was found profile had unique particular kinetic studies revealed proceeded extensively different rates. However, as judged by with HRV-1A, poliovirus, general mechanism synthesis, size, order remain same.