Nonsense-mediated RNA decay--a switch and dial for regulating gene expression.

摘要: Nonsense-mediated RNA decay (NMD) represents an established quality control checkpoint for gene expression that protects cells from consequences of mutations and errors during biogenesis lead to premature termination translation. Characterization NMD-sensitive transcriptomes has revealed, however, NMD targets not only aberrant transcripts but also a broad array mRNA isoforms expressed many endogenous genes. is thus emerging as master regulator drives both fine coarse adjustments in steady-state levels the cell. Importantly, while activity subject autoregulation means maintain homeostasis, modulation pathway by external cues provides reprogram drive important biological processes. Finally, unanticipated observation predicted lack protein-coding capacity are sensitive this translation-dependent surveillance mechanism implicates regulating function new diverse ways.