Rotaviruses preferentially bind O-linked sialylglycoconjugates and sialomucins

摘要: Rotaviruses are the most common cause of severe gastroenteritis in infants and children worldwide. Early events virus binding entry critical determinants cellular permissiveness to rotavirus replication. The only known ligands for rotaviruses sialic acids. We now report that simian bind preferentially a subset sialylated glycoconjugates, i.e. glycoproteins containing O-linked acid moieties. able distinguish between trisaccharide presented as neoglycolipids. Higher avidity by is explained multivalent clustered Our vitro data extended explain protective effect mucins murine model disease specific high molecular weight sialomucin infant mouse intestine. Rotavirus may be analogous selectin-mediated mechanisms adhesion, advantageous dynamic environment