Full N,N-Methylation of 4,4′-Methylenedianiline with Dimethyl Carbonate: A Feasible Access to 4,4′-Methylene bis(N,N-Dimethylaniline)

摘要: The full N,N-methylation of 4,4′-methylenedianiline (MDA) with dimethyl carbonate (DMC) was investigated. yield the major product 4,4′-methylene bis(N,N-dimethylaniline) (MBDMA) reached as high 97% over NaY catalyst at 190°C for 6 h. could be used two more times acceptable MBDMA yields higher than 90%. main by-products were identified three N-methylated derivatives. Surprisingly, formation N-methoxycarbonylation extremely restrained, which produced in 98% on zinc acetate catalyst. Furthermore, reaction pathway to proposed. Finally, a feasible synthetic route established, featuring yield, mild conditions, and simple operations.