Intra-individual variation of some serum constituents and its relevance to population-based reference ranges.

摘要: The advent of high-capacity multi-channel analyzers allows estimation long-term variability in serum constituents large numbers subjects. By frozen storage specimens with subsequent analysis a single machine run, analytical variation may be eliminated, thus sharpening the estimates intra-individual variation. In present study we used Vickers M-300 analyzer to obtain data for such from 37 male volunteers, each bled once week 22 weeks. Secimens were analyzed random order eliminate any biasing effect drift during 4-h run. Ten measured. Storage-induced linear trends small or negligible period specimen collection. Using ratio average within-subject variance among subjects as guide, alkaline phosphatase was found show greatest individuality, sodium and potassium least. Other constitutents showed varying degrees but all these analytes, usual population-based reference ranges either insensitive irrelevant concentration changes over time within most healthy Our results generally confirmed those smaller comparable earlier studies.