CYP7A1 gene polymorphism and the characteristics of dyslipidemias in patients with nonalcoholic fatty liver disease concurrent with hypothyroidism

摘要: Aim. To investigate the association of polymorphic variants -204A > C (rs 3808607) in CYP7A1 gene with development dyslipidemias healthy individuals, patients non-alcoholic fatty liver disease (NAFLD) and those NAFLD concurrent hypothyroidism. Subjects methods. DNA samples lipidograms were examined 180 patients, including 60 individuals (Group 1), hypothyroidism 2), 3). All underwent ultrasound examination thyroid gland abdominal cavity organs; FibroMax scores calculated. Results. study groups most frequently showed a homozygous AA genotype (86.6% cases Group 1, 80% 2, 83.3% The CC carriers is characterized by pronounced changes lipid metabolism (atherogenic index (AI), 7.32 3) compared to genotypes (AI, 4.56 2 1.73 1) 6.43 2.52 functional insufficiency hormones relative normal conditions. Conclusion. analysis relationship rs 38088607 metabolic disturbances that significantly higher levels atherogenic cholesterol fractions determined they did not depend on presence findings make it possible consider variant mutation as protective against dyslipidemia. However, hormones, level triglycerides both genotypes, which suggests plays an essential role dyslipidemia NAFLD.