Diversifying evolution of highly pathogenic H5N1 avian influenza virus in Egypt from 2006 to 2011
作者： E. M. Abdelwhab , Abdel-Satar Arafa , Jürgen Stech , Christian Grund , Olga Stech
DOI: 10.1007/S11262-012-0758-1
关键词:
摘要: An evolutionary analysis was conducted of 354 hemagglutinin (HA) and 208 neuraminidase (NA) genes, including newly generated sequences 5 HA 30 NA, Egyptian H5N1 clade 2.2.1 viruses isolated from poultry humans. Five distinct phylogenetically distinguishable clusters arose a monophyletic origin since 2006. Only two remained in circulation after 2009: (i) A cluster 2007 industrial-vaccinated chickens carried multiple mutations or adjacent to the immunogenic epitopes HA. Viruses within this evolved with significantly elevated mutation rates indicating persisting selective pressures, e.g. escape host immunity (ii) The second group 2008 harboured strains recent human infections featuring conspicuous deletion receptor-binding domain substitutions close highly conserved active site NA. In both sublineages, number positively selected amino acids, different glycosylation patterns variations polybasic proteolytic cleavage were observed. Continuous monitoring evolving virus Egypt is essential develop new control campaigns population.
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