Hemostatic Therapy in Experimental Intracerebral Hemorrhage Associated With the Direct Thrombin Inhibitor Dabigatran
作者： Wei Zhou , Sönke Schwarting , Sergio Illanes , Arthur Liesz , Moritz Middelhoff
DOI: 10.1161/STROKEAHA.111.624650
关键词:
摘要: Background and Purpose—Dabigatran-etexilate (DE) recently has been approved for stroke prevention in atrial fibrillation. However, lack of effective antagonists represents a major concern the event intracerebral hemorrhage (ICH). The aims present study were to establish murine model ICH associated with dabigatran, test efficacy different hemostatic factors preventing hematoma growth. Methods—In C57BL/6 mice receiving DE (4.5 or 9.0 mg/kg), vivo vitro coagulation assays dabigatran plasma levels measured repeatedly. Thirty minutes after inducing by striatal collagenase injection, received an intravenous injection saline, prothrombin complex concentrate (PCC; 100 U/kg), fresh-frozen (200 μL), recombinant human factor VIIa (8.0 mg/kg). volume was quantified on brain cryosections 24 hours later. Results—DE substantially prolonged tail vein bleeding time ecarin clotting 4 corresponding ...
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