Synthesis and properties of couplable ABCDE star copolymers by orthogonal CuAAC and Diels–Alder click reactions

摘要: The exploration on robust methods to construct star copolymers has attracted much attention. Owing the great challenge in synthesis, examples of miktoarm stars with chemical compositions up five or more are very scarce. This study aims at developing a modular and orthogonal approach synthesize multicomponent via one-pot strategy using distinct building blocks. Tandem CuAAC Diels–Alder reactions were utilized generate an ABCDE comprising poly(e-caprolactone) (PCL, A), poly(tert-butyl acrylate) (PtBA, B), poly(L-lactide) (PLLA, C), poly(N-isopropylacrylamide) (PNIPAM, D) poly(5-methyl-5-allyloxycarbonyl-1,3-dioxane-2-one) (PMAC, E) arms, subsequent hydrolysis afforded AB′CDE (B′ = poly(acrylic acid)) clickable dual-sensitive segments. liable self-assemble into intriguing morphologies involving vesicles, spherical micelles large compound which could be tuned by adopting thermal pH stimuli. synthesis chemistry allows us prepare ABCDE-type well-controlled molecular weight, tunable composition, versatile functions. success this further paves way for facile multifunctional quintopolymers their derivatives multipurpose applications.