[Physiology of novel AT1 receptor-binding molecule, ATRAP].

摘要: The AT1 receptor (AT1R)-associated protein (ATRAP) is a molecule specifically interacting with the carboxyl-terminal domain of AT1R. results in vitro studies showed that ATRAP suppresses Ang II-mediated pathological responses cardiovascular cells by promoting AT1R internalization. With respect to tissue distribution and regulation expression vivo, broadly expressed many tissues as Accumulating evidence indicates tissue-specific regulatory balancing may be involved modulation signaling at local sites also pathophysiology hypertension its associated end-organ injury. Furthermore, activation transgenic-models inhibited inflammatory vascular remodeling cardiac hypertrophy response II stimulation. These suggest clinical potential benefit an strategy treatment related organ