Constitutive expression of a tumor suppressor leads to tumor regression in a xenograft model
作者： Catherine Adams Burton , John Boylan , Candy Robinson , Janet Kerr , Pamela Benfield
DOI: 10.1007/978-3-0348-8468-6_6
关键词:
摘要: The machinery of the cell cycle provides a mechanism for duplication cellular DNA during division and appropriate distribution this to resulting daughter cells. It is important survival that process occurs in highly regulated controlled manner ensure accurate transmission genetic material. Dividing eukaryotic cells are equipped with surveillance mechanisms progression does not occur if conditions inappropriate, example, damaged or nucleotide supplies limiting. These have collectively been referred as checkpoint control. Failure control leads inappropriate accumulation damage hallmark human tumor [4, 5].
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