Differential effects of glucose on agonist-induced relaxations in human mesenteric and subcutaneous arteries.

摘要: Background and purpose: Acute periods of hyperglycaemia are strongly associated with vascular disorder, yet the specific effects high glucose on human blood vessel function not fully understood. In this study we (1) characterized endothelial-dependent relaxation two similarly sized but anatomically distinct arteries to different agonists (2) determined how these responses modified by acute exposure glucose. Experimental approach: Ring segments mesenteric subcutaneous were mounted in a wire myograph. Relaxations acetylcholine bradykinin control (5 mM) (20 mM) environment over 2 6 h incubation period. Key results: Bradykinin-induced both sets vessels was mediated entirely EDHF whilst that generated acetylcholine, though principally EDHF, also had contribution from prostacyclin possibly nitric oxide vessels, respectively. A 2-h impaired bradykinin-induced whilst, contrast, enhanced at same time point. High significantly augmented point, respectively. Conclusions implications: Short exert variable influence endothelial isolated is dependent factors time, agonist-used studied. This has implications for view found patients diabetes mellitus as well other conditions. British Journal Pharmacology (2008) 153, 480–487; doi:10.1038/sj.bjp.0707592; published online 26 November 2007