Optical imaging and anticancer chemotherapy through carbon dot created hollow mesoporous silica nanoparticles.

摘要: Abstract Multifunctional nanocarrier-based theranostics is currently considered to solve some key unmet challenges in cancer treatment. Here we report a nanocarrier platform, named carbon dot (CD) created mesoporous hollow organosilica (C-hMOS) nanoparticles, deliver anticancer drug and enable optical imaging. The structure was formed by the removal of nanorod core template, at same time, fluorescent signal endowed from heat-treated network. Thanks structure, C-hMOS effectively loaded doxorubicin (DOX) for chemotherapy. DOX released highly sustainably (over 12 days) pH-dependently (pH 5.0 > pH 7.4). DOX-loading internalized cells efficiently (>90%), induced cellular apoptosis including expression caspase-3. treatment enabled multi-color visualization vitro, suggesting possibility cell tracing. Moreover, when injected intratumorally mice, exhibited strong signals vivo along with high stability week). were distributed only fraction liver but not heart, lung, spleen or kidney displayed good biocompatibility. DOX-delivering significantly suppressed tumor growth associated apoptotic functions. Taken together, developed nanoparticles can be promising nanoplatform delivery imaging Statement Significance that combine chemotherapeutic ability modality comprise platform theranostics. novel theranostic nanoparticle, i.e., carbon-dot silica offer unique merit this purpose. vitro findings support include: i) dots 1–2 nm size situ generated discretely uniformly within network, ii) effective loading content, iii) release behavior sustainable pH-dependent manner, iv) efficacy killing suppressing through delivery, v) fluorescence tissues. These collective multifaceted properties may facilitate nanocarriers potential candidate delivering non-invasive