Dominant negative and cooperative effects of mutant forms of prolactin receptor.
作者： Martine Perrot-Applanat , Oreste Gualillo , Alain Pezet , Valérie Vincent , Marc Edery
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摘要: In addition to a long form of 591 amino acids (aa), two other forms PRL receptor (PRLR), differing in the length their cytoplasmic domains, have been identified rat. The Nb2 form, lacking 198 aa domain, is able transmit lactogenic signal similar whereas short 291 inactive. ability activate promoter theβ -casein gene or hormone responsive element fused luciferase reporter was assessed Chinese hamster ovary cells 293 fibroblasts transiently transfected with PRLR cDNAs. function examined after cotransfection both and forms. These results clearly show that acts as dominant negative inhibitor through formation inactive heterodimers, resulting an inhibition Janus kinase 2 (JAK2) activation. present study also investigates possible participation receptors transduction pathway, using ...
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