Nitric oxide and immune response.
作者： Parul Tripathi
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摘要: Nitric oxide (NO), initially described as a physiological mediator of endothelial cell relaxation plays an important role in hypotension. It is intercellular messenger and has been recognized one the most versatile players immune system. Cells innate system--macrophages, neutrophils natural killer (NK) cells use pattern recognition receptors to recognize molecular patterns associated with pathogens. Activated macrophages then inhibit pathogen replication by releasing variety effector molecules, including NO. In addition macrophages, large number other system produce respond Thus, NO toxic defense molecule against infectious organisms. also regulates functional activity, growth death many inflammatory types T lymphocytes, antigen-presenting cells, mast NK cells. However, non-specific specific immunity vivo immunologically mediated diseases inflammation poorly understood. This review discusses response its mechanisms action these processes.
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