Regulatory role of IgE-binding factors from rat T lymphocytes. V. formation of IgE-potentiating factor by T lymphocytes from rats treated with Bordetella pertussis vaccine.

摘要: An i.p. injection of Bordetella pertussis vaccine (BP) into rats induced the formation soluble factors that had affinity for IgE (IgE-binding factors). The factor was detected in serum BP-treated animals 5 to 7 days after treatment. Their circulating lymphocytes as well spleen cells spontaneously released IgE-binding and those from their lentil lectin, ability selectively potentiate an vitro response DNP-OA primed homologous antigen. molecular size IgE-potentiating between 10,000 20,000, comparable formed by infected with Nippostrongylus brasiliensis. Evidence obtained derived Fc epsilon R(+) T cells, a cell marker identified monoclonal antibody W 3/25. production may be basis adjuvant effect BP on response.