Allelotyping of esophageal squamous-cell carcinoma on chromosome 13 defines deletions related to family history.

摘要: We previously reported that esophageal squamous-cell cancers (ESCC) from Shanxi Province in China show frequent allelic loss on chromosome 13. Moreover, tumors patients with a positive family history of upper gastrointestinal exhibit more heterozygosity (LOH) this than do those without history. These results suggest the possibility familial ESCC susceptibility gene. To investigate phenomenon further, we performed an in-depth analysis allelic-loss data sets both and tumors. Comparisons between deletion frequency location were made respect to status, risk factors, clinical/pathologic characteristics The confirmed tumor LOH was significantly higher who family-history-negative, four common regions these family-history-positive defined. Statistically significant associations also observed grade location, as well presence lymph node metastases. Taken together, indicate gene or genes 13 play important role etiology progression ESCC.