Synthesis, Characterization, and Evaluation of Redox-Sensitive Chitosan Oligosaccharide Nanoparticles Coated with Phycocyanin for Drug Delivery.
作者： Ziting Cheng , Wei Zhang , Xiaoya Hou , Bingjie Wang , Yanping Zhu
DOI: 10.1186/S11671-019-3207-4
关键词:
摘要: In this paper, a type of phycocyanin (PC)-functionalized and curcumin (CUR)-loaded biotin-chitosan oligosaccharide-dithiodipropionic acid-curcumin (BCSC) nanoparticles, called CUR-BCSC@PCs, were designed to enhance the biocompatibility CUR. The structure BCSC was confirmed using 1H-NMR. CUR-BCSC@PCs with an average hydrodynamic diameter 160.3 ± 9.0 nm, biomimetic protein corona gave nanoparticles excellent stability potential avoid adsorption in blood circulation. vitro release experiment verified that redox responsive shells sensitive high concentrations glutathione. addition, effective at increasing inhibitory activity on proliferation A549 cells by enhancing intracellular uptake These results indicated have great application prospects cancer therapy as drug delivery carriers.
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