Generalized argyrosis in man: neurotological, ultrastructural and X-ray microanalytical findings

摘要: Generalized argyrosis can produce a number of abnormalities, including skin discoloration, liver and kidney dysfunction. We describe patient with generalized following long-term self-treatment oral silver intake, in whom progressive taste smell disorders, vertigo hypesthesia were observed. These findings confirmed by chemosensory tests electrophysiological investigations. The development hypogeusia was assessed subjective tests, while the progression hyposmia followed recording olfactory evoked cortical potentials. Light electron microscopy tissue samplings demonstrated electron-dense mineral deposits basal membranes, macrophages, perineurium peripheral nerves, along elastic collagenous fibers, necrotic cells submucosa. Silver sulfur affected tissues could be defined X-ray microanalysis. quantitative ratio between involved similar to that an inorganic silver-sulfide (Ag2S) standard. minute increase content when compared standard suggested containing organic matrix precipitates. Our indicate affinity for membrane neuronal structures deposition as insoluble compound induce clinical disease.