Relative frequency of Haemophilus influenzae type b pneumonia in Chinese children as evidenced by serology.

摘要: Objectives. It is commonly held that Haemophilus influenzae pneumonia among children in Asia mostly caused by serotypes other than b (Hib). If so, Hib conjugate vaccines would play little role the prevention of pneumonia. In two prospective series hospitalized for China, causative agents were searched with a wide panel microbiologic assays. Methods. university hospitals Beijing and Hefei, 156 consecutive 3 months age older symptoms signs studied. Blood culture, chest radiograph, nasopharyngeal aspirate viral antigen detection paired sera 20 assays taken. Severity was graded, course illness monitored uniformly. Results. only likely contaminants grew from blood cultures, Hefei pathogens identified cases. combined evidence bacterial, mixed etiology obtained 30, 7 21% cases, respectively. The dominant bacteria pneumococcus, Hib, Mycoplasma pneumoniae Chlamydia pneumoniae, responsible 13, 10, 8 8% Most patients treated extended spectrum antimicrobials such as piperacillin, cefotaxime or ceftriaxone, alone combination. One child died. Conclusions. As most countries, leading agent causing childhood pneumococcus but, line our previous experience Beijing, second common detected Hib. This observation suggests great potential pneumococcal vaccinations China. Because no supported need routine use antimicrobials, narrower be safer patients, cheaper community offer way to address increasing resistance problems.