Free Radical Scavengers and Spin Traps

摘要: This chapter explores the role of free radical scavengers and spin trapping agents in preventing cell death. Reactive oxygen species (ROS) can be generated ischemic/reperfused tissues by a number pathways. Electron transport associated with mitochondrial membranes is major contributor to ROS formation normoxic brain. Enhancement oxidative metabolism during reperfusion phase following an ischemic episode may result overwhelming endogenous antioxidant capacity tissues. Purine provides another potential source ROS. Because failure phosphorylation, ATP levels decline precipitously, adenosine its metabolites inosine hypoxanthine. Experimental evidence strongly implicates chain events leading ischemia/reperfusion-related neuronal injuries. Free scavengers, spin-trapping agents, inhibitors synthesizing enzymes are able interrupt reaction lipid peroxidation which cause extensive destruction plasma, nuclear, membranes, cellular metabolism, homeostasis, ultimately Agents such as trap agent N - t -butyl-α-phenylnitrone 21-aminosteroid, tirilazad mesylate, appear offer promising new avenues approach prevention treatment cerebral